Gut microbiota and metabolite profiles in HBV cirrhosis with persistent liver enzyme abnormalities.

ABSTRACT:

Background and aims

Dysbiosis of gut microbiota and metabolic disturbances are implicated in the progression of hepatitis B virus (HBV)-related cirrhosis. However, the mechanisms underlying these associations, particularly in patients with undetectable HBV-DNA following antiviral therapy but persistent liver enzyme abnormalities, remain poorly understood. This study aimed to characterize the gut microbiota and metabolic profiles in this patient population to elucidate potential mechanisms and identify biomarkers.

Materials and methods

Sixty-five patients with HBV-related cirrhosis were enrolled. Fecal samples were analyzed using 16S rRNA gene sequencing and untargeted liquid chromatography-mass spectrometry (LC-MS) to assess gut microbiota composition and metabolite profiles

SUBMITTER: He H 

PROVIDER: S-EPMC12549703 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature