Intravenous thrombolysis in patients with acute ischaemic stroke and active cancer (the ITACA-stroke study).

ABSTRACT:

Background and aim

Current data regarding the effect of intravenous thrombolysis (IVT) in patients with acute ischaemic stroke (AIS) with concomitant malignancy remain unclear. This study aimed to evaluate the efficacy and safety of IVT in patients with AIS and concomitant active cancer.

Methods

The ITACA-stroke study was a retrospective observational study based on prospective registries of a multicentre international collaboration. Patients with a diagnosis of active cancer and AIS, treated or not with IVT, were enrolled. Multivariable logistic regression analysis was performed to identify independent predictors for functional outcomes (mortality and good functional outcome) and haemorrhagic events at 90 days. A propensity score matching (PSM) analysis compared IVT and no-

SUBMITTER: Cancelloni V 

PROVIDER: S-EPMC12549749 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature