Anaerobic bio-reduction ignites persistent photothermal conversion in misaligned porphyrin supramolecular assembly for infected wound regeneration.

ABSTRACT: To address the dual challenges of antibiotic resistance and microbial dysbiosis caused by non-selective photothermal therapy, we engineered an intelligent nanosystem (TPPS₄-Ca) achieving specific recognition and localized photothermal eradication by pathogens. The innovative out-of-plane coordination between Ca²⁺ and anionic porphyrin (TPPS₄) constructs redox-responsive self-assemblies, which not only suppresses the common self-quenching effect of porphyrin aggregation but also significantly enhances the electrostatic targeting toward negatively charged bacteria. Moreover, within the hypoxic microenvironment of facultative anaerobes, TPPS₄-Ca undergoes selective reduction to phlorin/chlorin species with exceptional near-infrared (NIR) phototherma

SUBMITTER: Wang X 

PROVIDER: S-EPMC12549777 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature