The role of circadian rest-activity rhythm for the link between 25-hydroxyvitamin D and type 2 diabetes: a cohort study.

ABSTRACT:

Background

Temporal distribution and amplitude of physical activity/inactivity in 24 h known as circadian rest-activity rhythm may predict the risk of various metabolic diseases, including type 2 diabetes (T2D), yet the mechanisms behind the diurnal behavior patterns remain largely unexplored.

Methods

This study included 74,165 UK Biobank participants who were free of T2D at baseline. Circadian rest-activity rhythm (CRAR) characteristics, including amplitude (strength), acrophase (timing of peak activity), pseudo-F (robustness), and mesor (height), were assessed using an extended cosine model applied to accelerometer data. T2D was assessed using the established UK Biobank algorithms. Using Cox regression and restricted cubic spline models, we examined the association between

SUBMITTER: Wu H 

PROVIDER: S-EPMC12549808 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature