Study of epinephrine-induced cardiovascular adverse events in patients with anaphylaxis using two spontaneously reported adverse event databases from 2004 to 2024.

ABSTRACT: Anaphylaxis is a life-threatening hypersensitivity reaction requiring prompt administration of epinephrine. Despite its life-saving role, hesitancy in epinephrine use persists, largely due to concerns about cardiovascular adverse events (AEs). This study aimed to characterize potentially epinephrine-induced cardiovascular AEs in anaphylaxis using data from two major pharmacovigilance databases. A retrospective analysis was conducted using individual case safety reports (ICSRs) from the US FDA Adverse Event Reporting System (FAERS) and the European EudraVigilance database from 2004 to 2024. ICSRs were included if epinephrine was a suspect drug and the indication involved anaphylaxis or related terms. Reports were screened for cardiovascular AEs and assessed for causality by two independent

SUBMITTER: Kamath P 

PROVIDER: S-EPMC12549901 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature