Identification and characterization of tissue- and stress-specific circular RNAs (circRNAs) of tea to generate the largest tea circRNAs data repository.

ABSTRACT: Enormous RNA-seq data of tea (Camellia sinensis) is available at NCBI, yet only 3,174 circular RNAs (circRNAs) have been reported to date. This study establishes a foundation for using public datasets to generate circRNA reservoirs. After standardizing the pipeline using in-house RNA-seq data from Indian tea, 178 RNA-seq datasets of tea were downloaded from NCBI and used for the generation of the largest tissue and stress-specific tea circRNAs repository (TCDB; http://indianteagenome.in:8080/tcdb/ ), till date. A total of 3052 and 59,575 full-length circRNA isoforms were identified from Indian tea and downloaded public datasets, respectively. Notably, only 10% of these shared homologies with known plant circRNAs, indicating that 90% are novel. Since only 9.77% circRNAs were shared between

SUBMITTER: Rawal HC 

PROVIDER: S-EPMC12549911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature