Metabolomics for searching non-invasive biomarkers of metabolic dysfunction-associated steatotic liver disease in youth with vertical HIV.

ABSTRACT:

Background

In adults living with HIV, non-invasive biomarkers have been described for the early identification of metabolic dysfunction-associated steatotic liver diseases (MASLD). However, this issue remains unexplored in children and young people with vertical HIV (YWVH), among whom MASLD prevalence is around 30%.

Methods

To identify biomarkers associated with MASLD in YWVH under sustained viral suppression with antiretroviral therapy, we analysed plasma lipid species, plasma bile acid profile, and gut microbiome composition in a cross-sectional cohort of 10 YWVH with MASLD and 19 YWVH without clinical evidence of MASLD (control).

Results

Here we show that YWVH with MASLD have significantly increased circulating levels of eight specific lipid molecules and one bile

SUBMITTER: Chafino S 

PROVIDER: S-EPMC12549917 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature