Parkinson's disease, herpes simplex virus type 1, and nanopore sequencing: A case analysis.

ABSTRACT: Parkinson's disease (PD) is a chronic neurodegenerative disorder that impacts the central nervous system, primarily the motor nervous system. Patients frequently experience respiratory muscle dysfunction, which can lead to swallowing disorders, coughing, ultimately inducing aspiration pneumonia. PD patients in the intensive care unit (ICU) are at risk of being infected with drug-resistant pathogens. This case report presents a PD patient with aspiration pneumonia. As the patient did not show improvement after empirical treatments such as antibiotics, nanopore targeted sequencing (NTS) was employed to detect pathogens in bronchoalveolar lavage fluid in real time, enabling timely detection of HSV-1 infection and adjustment of the treatment strategy. Additionally, whole-exome sequencing (WES)

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12549925 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature