Enhanced lymphocyte infiltration in the liver of LDL receptor and Myeloid Differentiation 1 double knockout mice on high fat diet.

ABSTRACT: Myeloid differentiation 1 (MD-1; gene name: ly86), a glycoprotein that forms a complex with radioprotective protein 105 (RP105), is involved in the regulation of inflammation, obesity, and insulin resistance. Previous reports have shown an exacerbation of cardiac pathology in MD-1 deficient mice, including pressure overload-induced cardiac remodeling and high fat diet (HFD) -induced inflammatory atrial fibrosis. Furthermore, MD-1 expression is upregulated in atherosclerosis, as indicated by DEG database analysis, and is present in human atherosclerotic plaques. However, its involvement in atherosclerosis is unclear. In this study, we analyzed the effect of MD-1 deficiency on the development of HFD-induced atherosclerosis in littermates of low-density lipoprotein (LDL) receptor-deficient mi

SUBMITTER: Biswas M 

PROVIDER: S-EPMC12549959 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature