Immunosuppressive therapy in patients with biopsy-proven inflammatory myocardial disease: a systematic review and meta-analysis.

ABSTRACT: The aim of this study was to evaluate and update the effects of immunosuppressive therapy on heart failure outcomes in patients aged 16 years or older with biopsy-proven inflammatory myocardial disease. We performed a systematic review and an aggregate data meta-analysis of studies evaluating the effects of such therapy in acute and chronic myocarditis or inflammatory dilated cardiomyopathy. Studies were chosen based on criteria related to clinical relevance for therapeutic decisions and measured outcomes in left ventricular ejection fraction (LVEF) and New York Heart Association classification (NYHA) at 3, 6, and 12 months. Data sources included PubMed, Embase, Ovid, and ClinicalTrials.gov, with manual reference checks. Data extraction and risk-of-bias assessments were performed by two in

SUBMITTER: Stautner B 

PROVIDER: S-EPMC12550003 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature