Characterizing volatile organic compound profiles in oral cancer using multiple sample collection approaches by GC-IMS and TD-GC-MS.

ABSTRACT: Oral cancer (OC) is an aggressive malignancy with poor prognosis due to late-stage diagnosis and limited early detection tools. Volatile organic compounds (VOCs) have emerged as potential biomarkers for early OC detection, offering a non-invasive approach. However, the optimal sample collection and analytical workflow remains unclear. This study compares the diagnostic potential and clinical feasibility of exhaled breath, lesional air, and lesional brushings using thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) and gas chromatography-ion mobility spectrometry (GC-IMS). Twenty-six participants (13 OC or high-grade lesion patients, 13 controls) were recruited. Multivariate analysis assessed group separation and identified key discriminatory features. TD-GC-MS detected more

SUBMITTER: Borden SA 

PROVIDER: S-EPMC12550030 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature