Exploring GNRA tetraloop-like motifs in nucleic acid 3D structures.

ABSTRACT: Structured nucleic acids play key roles in a variety of molecular mechanisms and have numerous applications in medicine and biotechnology. Stem-loops with specific tetraloop sequences, such as UNCG and GNRA, are among the most well-studied recurrent building blocks of structured RNAs, known to adopt very stable structures. The GNRA tetraloop motif frequently engages in long-range interactions with specific RNA receptors and can also be recognized by proteins. While several examples of GNRA-like conformations have been reported in non-tetraloop strands, no systematic survey has been conducted to explore the landscape of these variants. In this work, we report a comprehensive survey of GNRA tetraloop-like motifs within known 3D structures of nucleic acids, based solely on isostericity and wi

SUBMITTER: Bujnicki JM 

PROVIDER: S-EPMC12550061 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature