Cancer-associated fibroblasts promote tumor progression in fusion-positive rhabdomyosarcoma.

ABSTRACT: In children, rhabdomyosarcoma is the most common tumor originating in soft connective tissue. The PAX3/PAX7-FOXO1 fusion-positive alveolar subtype has poor clinical outcomes, with frequent recurrence, metastasis, and low survival. Current therapies may be limited by the tumor microenvironment containing cancer, immune, and fibroblast cells. In cancer, cells that transform into cancer-associated fibroblasts support growth and other malignant properties of the tumor. To study the role of cancer-associated fibroblasts, we isolated cells from the lung metastases of a patient with rhabdomyosarcoma that are positive for fibroblast biomarkers. Compared to normal lung fibroblasts, these cancer-associated fibroblasts secreted distinct factors that specifically supported the growth and migration of

SUBMITTER: Sipila P 

PROVIDER: S-EPMC12550101 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature