Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses.

ABSTRACT:

Objective

Sociodemographic, lifestyle, and medical variables influence total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations. The relationship between these factors and "free" T remains unclear. We examined 21 sociodemographic, lifestyle, and medical predictors influencing calculated free T (cFT) in community-dwelling men across ages.

Design

This is a cross-sectional analysis in 20 631 participants in the Androgens in Men Study.

Methods

Individual participant data (IPD) were provided by 9 cohorts. Total T was determined using mass spectrometry, SHBG using immunoassays, and cFT using the Vermeulen formula. Associations were analyzed using 2-stage random effects IPD meta-analyses.

Results

Cohort median ages ranged from 40 to 76 years and m

SUBMITTER: Narinx N 

PROVIDER: S-EPMC12550126 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature