The Impact of Bulbar and Upper Motor Neuron Involvement on Oculomotor Movement in Amyotrophic Lateral Sclerosis.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of both lower and upper motor neurons (UMN). Clinical heterogeneity manifests in subtypes such as bulbar-onset ALS (bALS) and spinal-onset ALS (sALS), with emerging evidence suggesting that oculomotor dysfunction may reflect broader multisystem involvement. This study aims to investigate oculomotor parameters across different ALS phenotypes and their associations with neuropsychological domains.

Methods

A total of 46 patients meeting the Gold Coast Criteria for ALS were enrolled, alongside 23 age- and education-matched healthy controls (HCs). Participants were assessed for demographic variables and clinical features, and underwent cognitive and oculomot

SUBMITTER: Shen D 

PROVIDER: S-EPMC12550129 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature