Network Pharmacology and Molecular Docking Elucidate the Mechanism of Phillyrin in Colorectal Cancer.

ABSTRACT: Phillyrin is an important active component of the traditional Chinese medicinal herb Forsythia suspensa Vahl (Oleaceae) and has demonstrated anti-inflammatory, antioxidant, and antitumor properties. However, there is a paucity of studies investigating its therapeutic efficacy in colorectal cancer (CRC). Our research aims to explore the potential therapeutic effects and underlying mechanisms of phillyrin in treating CRC. Phillyrin potential targets were predicted using the ChEMBL, HERB, and SwissTargetPrediction databases. TCGA and GEO databases were employed to acquire targets associated with CRC. Afterward, we used the STRING web database to perform network analysis of protein-protein interactions (PPI) on the shared genes. Key genes were discovered in the PPI network and subsequen

SUBMITTER: Hu ZJ 

PROVIDER: S-EPMC12550133 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature