Hydrogen sulfide to modulate Glycated hemoglobin and gut microbiome in type 2 diabetes mellitus.

ABSTRACT:

Aims

Hydrogen sulfide (H₂S) is a gasotransmitter implicated in carbohydrate metabolism. This study explored associations between circulating H₂S, glucose homeostasis, and gut microbiome composition in type 2 diabetes mellitus (DM).

Methods

Blood H₂S levels were quantified by HPLC in 93 DM patients; insulin resistance was assessed using HOMA-IR. Gut microbiota from 38 patients were analyzed via Oxford Nanopore 16S rRNA sequencing. Analyses were stratified by median H₂S and HbA1c values.

Results

Median H₂S and HbA1c levels were 22.65 μM and 7 %, respectively. Patients with H₂S ≥ 22.65 μM were more likely to have HbA1c ≥ 7 % (OR: 2.75; 95 % CI: 1.18-6.38; p = 0.022). Higher H₂S was linked

SUBMITTER: Katopodis S 

PROVIDER: S-EPMC12550158 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature