Micronutrient Biomarker Selection and Assay Methods and Performance in Double-Blind, Randomized, Controlled Micronutrient Dose Response (MiNDR) Trials among Women of Reproductive Age and Pregnant Women in Rural Bangladesh.

ABSTRACT:

Background

Comprehensive documentation of micronutrient biomarker assessments, capturing status from deficiency to excess, remains limited, specifically in the context of multiple micronutrient supplementation (MMS) trials.

Objectives

We document biomarker selection, preanalytical and analytical methods, assay performance evaluation, and biomarker interpretation for modeling the dose-response effects of MMS in 2 parallel bioefficacy trials among women of reproductive age and pregnant women in rural Bangladesh.

Methods

Blinded analysis of biomarker assays is being performed in the field and at 2 laboratories. Automated clinical chemistry analyzers are used to measure conventional serum and plasma biomarkers of vitamin D, B12, folate, iron, inflammation, iodine, and bon

SUBMITTER: Bandyopadhyay S 

PROVIDER: S-EPMC12550162 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature