Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.

ABSTRACT: Promoting the maturation of dendritic cells (DCs) is crucial for effectively activating the adaptive immune response. Nevertheless, DC maturation and subsequent antigen presentation were impeded by the immunosuppressive tumor microenvironments (TME). Herein, a cascade amplification strategy for the activation of antitumor immune response is reported for the first time based on a biodegradable Cu-based sonozyme, which integrates ROS-mediated immunogenic cell death (ICD), immune checkpoint blockade (ICB), cuproptosis, and cGAS-STING activation. An in-situ phosphating strategy was employed to synthesize Cu₃P sonozymes from Cu₂O nanocubes. Different from the pristine Cu₂O, the obtained Cu₃P nanocubes possess the TME-responsive degradation features, w

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12550172 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature