Glucose-responsive nanozyme hydrogel for glycemic control and catalytic anti-infective therapy in diabetic wound healing.

ABSTRACT: Diabetes-induced impairment in glycemic regulation delays wound healing by promoting bacterial infection, oxidative stress, and vascular injury. To address these challenges, we developed a glucose-activated, self-switchable nanozyme-hydrogel platform capable of intelligent, on-demand insulin release synchronized with blood glucose fluctuations, thereby achieving closed-loop glycemic control while promoting tissue repair. This multifunctional system integrates glucose oxidase (GOx) and insulin within bimetallic Zn-Fe metal organic framework nanoparticles (MOF(Zn-Fe)/GOx/INS), which are embedded in a ROS-responsive hydrogel. Under hyperglycemic conditions, GOx catalyzes glucose oxidation to gluconic acid and H₂O₂, generating a mildly acidic microenvironment. This acidit

SUBMITTER: Tai QD 

PROVIDER: S-EPMC12550175 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature