Risk conditions for invasive pneumococcal disease in adults: a systematic review and meta-analysis.

ABSTRACT:

Background

The burden of invasive pneumococcal disease (IPD) in adults remains high despite vaccination programs. Age is currently the prime criterion used to define target groups for prevention. To support effective intervention programs, we investigated the relative importance of risk conditions associated with adult IPD.

Methods

We conducted a systematic search in PubMed and Embase and included all original studies published before March 24th 2025 that reported risk estimates for adult IPD in individuals with risk conditions, compared to the general population (PROSPERO ID 417980). Risk estimates were extracted and meta-analyses were performed for conditions supported by more than one study. Pooled incidence rate ratios with 95% confidence intervals (IRRs (95% CIs)) were

SUBMITTER: Ditzel K 

PROVIDER: S-EPMC12550179 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature