Silicified strontium-curcumin chelated nanospheres mitigate inflammatory vicious cycles to accelerate diabetic wound healing.

ABSTRACT: In diabetic wounds, the overexpression of reactive oxygen species (ROS) and the imbalance of the immune microenvironment surrounding immune cells, such as macrophages, can trigger a vicious cycle of inflammation in the wound area, a key factor contributing to impaired wound healing. To effectively address this challenge, this study innovatively harnessed the chelation-synergistic effect between strontium (Sr) ions, which possess immune-regulating functions, and curcumin (Cur), which exhibits antioxidant properties, to develop and design silicified strontium-curcumin chelated nanospheres (Sr-Cur NPs) with dual functions of anti-ROS and immune regulation. Subsequently, these nanospheres were formulated into a composite hydrogel (Sr-Cur@Alg) using sodium alginate. Sr-Cur@Alg successfully bloc

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12550185 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature