Dual-domain engineered exosome-based self-powered microneedle delivery platform for the treatment of infected wounds.

ABSTRACT: Bacterial infection and persistent inflammation severely hinder tissue regeneration; therefore, a synergistic therapeutic strategy that combines antibacterial and pro-healing functions is crucial for the effective treatment of infected wounds. In this study, we construct a self-powered microneedle drug delivery platform based on a Dual-domain engineered exosome (D²-Exo) that integrates antimicrobial and healing-promoting capabilities. The exosome is internally loaded with asiaticoside and surface-modified with an antimicrobial peptide. The self-powered microneedle delivery platform, driven by a triboelectric nanogenerator, enables precise and efficient release of the D²-Exo. In vitro and in vivo experiments show that electrical stimulation significantly

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12550190 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature