Lipidomic signatures in maternal blood and placenta: Systematic evidence linking lipid profiles to pregnancy outcomes and fetal growth.

ABSTRACT:

Introduction

Pregnancy involves profound metabolic adaptations, particularly in lipid metabolism. Disruptions in lipid profiles have been implicated in obstetric complications, yet no systematic synthesis of lipidomic evidence exists across diverse pregnancy outcomes. The primary objective of this review was to identify and synthesize consistent lipid species and lipid classes across studies of maternal and fetal biospecimens, in relation to adverse pregnancy outcomes.The secondary objective was to evaluate the potential predictive and prognostic utility of lipidomic signatures for risk stratification, including their capacity to provide early biomarkers and to inform postpartum metabolic surveillance.

Methods

A systematic search of five databases (PubMed, Scopus, EMBASE, We

SUBMITTER: Kalapouti E 

PROVIDER: S-EPMC12550197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature