Intracellular interaction between FcRY receptor and IgY in ovarian vascular endothelial cells during avian maternal IgY transfer.

ABSTRACT: Maternal immunoglobulin Y (IgY) is transferred from the bloodstream to the yolk of maturing oocytes in avian species, which is crucial for the passive immunity of neonatal chicks. The receptor responsible for maternal blood IgY transfer to the yolk remains unidentified. Recently, we found that an IgY receptor, FcRY, is expressed in the vascular endothelial cells of ovarian follicles. However, there is no evidence of the direct binding of IgY to FcRY in vascular endothelial cells of avian ovarian follicles. To investigate how ovarian FcRY interacts with IgY, we performed a microscopic analysis of FcRY-IgY interactions in the primary endothelial cells isolated from quail ovarian follicles. Western blot and real-time PCR analyses showed that FcRY was expressed in the vascular endothelial cell

SUBMITTER: Okamoto M 

PROVIDER: S-EPMC12550237 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature