NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognition.

ABSTRACT: Diffusion tensor imaging has traditionally been used to assess white matter (WM) integrity in Alzheimer's disease (AD). However, the tensor model is limited in modeling complex WM structure. Neurite Orientation Dispersion and Density Imaging (NODDI), a cutting-edge technique applied to multishell diffusion MRI, can offer more precise insights into microstructural features of WM integrity. We assessed whether NODDI more sensitively detects AD-related changes in medial temporal lobe (MTL) WM than traditional tensor metrics. In total, 199 older adults with multishell diffusion MRI from ADNI3 (mean age = 75 years; 60% female; cognitively unimpaired, n = 121; cognitively impaired MCI/dementia, n = 77) were analyzed. Tensor metrics of fractional anisotropy (FA) and mean diffusivity (MD), as well

SUBMITTER: Parker DM 

PROVIDER: S-EPMC12550277 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature