TERT expression attenuates metabolic disorders in obese mice by promoting adipose stem and progenitor cell expansion and differentiation.

ABSTRACT:

Background and aims

Adipose tissue (AT) senescence, induced by obesity or aging, leads to a reduced capacity for tissue remodeling and a chronic pro-inflammatory state, which leads to the onset of metabolic pathologies. Cellular senescence is triggered by various stresses, in particular excessive shortening of telomeres, which activates the p21 pathway and leads to the arrest of the cell cycle. We used the mouse model p21^+/Tert expressing TERT from the Cdkn1a locus to investigate whether counteracting telomere shortening by telomerase (TERT) specifically in pre-senescent cells could improve obesity-induced metabolic disorders.

Results

Our study demonstrates that conditional expression of TERT reduces insulin-resistance and glucose intolerance associated with obesi

SUBMITTER: Braud L 

PROVIDER: S-EPMC12550303 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature