Expression and interaction of RNA binding protein HuR with multidrug transporters (P-GP, MRP1, and ABCG2) in chemoresistant breast and colorectal cancer cells.

ABSTRACT:

Background

Chemoresistance poses a significant challenge in cancer treatment. Over expression of efflux pumps is one of the primary mechanisms that confer chemoresistance. P-GP, MRP1, and ABCG2, which are important ABC efflux pumps, collectively facilitate the transportation of a wide range of chemotherapeutic drugs out of cells. HuR is known to regulate the expression of various oncogenes through several ways, such as enhancing mRNA trafficking, facilitating mRNA stabilization, and protein translation. This study aimed to investigate the expression pattern of HuR as well as the co-expression pattern of ABC transporters (P-GP, MRP1, and ABCG2) with HuR in chemoresistant breast and colorectal cancer tissues to gain insights into the mechanisms of chemoresistance.

Methods

Immu

SUBMITTER: Nath SD 

PROVIDER: S-EPMC12550304 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature