The impact of the PNPLA3 rs738406 C>G polymorphism on hepatocellular carcinoma risk in Brazilian patients with chronic hepatitis C and advanced fibrosis.

ABSTRACT:

Introduction

The PNPLA3 rs738409 C>G polymorphism has been associated with fibrosis and steatosis in Chronic Hepatitis C (CHC) patients. However, its impact on Hepatocellular Carcinoma (HCC) development in this population remains unclear. This study aimed to evaluate the impact of the PNPLA3 polymorphism on the risk of HCC development in CHC patients in Brazil.

Methods

This retrospective case-control study included 235 CHC patients with advanced fibrosis, 119 with HCC, and 116 without HCC. The PNPLA3 polymorphism was analyzed using both the dominant and recessive models. Multivariate logistic regression was performed to assess factors independently associated with HCC development.

Results

The HCC group exhibited a higher proportion of male patients (p < 0.0001), alcoh

SUBMITTER: Maccali C 

PROVIDER: S-EPMC12550332 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature