Relationship between vitamin D deficiency, vitamin D receptor gene variants, & the risk of coronary artery disease among South Indians: A case-control study.

ABSTRACT: Background & objectives Vitamin D deficiency (VDD) and variations in the vitamin D receptor (VDR) gene are implicated in the pathogenesis of coronary artery disease (CAD). This study investigated the association between VDD, VDR gene variants (ApaI, BsmI, FokI, and TaqI), and CAD risk among South Indians. Methods The case-control study was conducted in 250 CAD patients and 260 matched controls. Serum vitamin D levels were measured by ELISA. Genotyping for VDR ApaI (A>C, rs7975232), BsmI (A>G, rs1544410), FokI (T>C, rs2228570), and TaqI (C>T, rs731236) was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results VDD was significantly higher among CAD patients (90%) than in controls (63%). Individuals with vitamin D levels <20 ng/ml we

SUBMITTER: Prakash N 

PROVIDER: S-EPMC12550383 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature