Erythroid activity modulates iron regulation in pathological erythropoiesis: A cross-sectional case-control study.

ABSTRACT: Background & objectives Genetic defects and altered synthesis of RBCs characterise β-thalassemia and polycythaemia vera (PV), respectively. In both diseases, stress erythropoiesis leads to accelerated erythroid expansion, although iron regulation has not been well studied. Here, we analysed iron parameters and iron regulatory gene expression in individuals affected with β-thalassemia and PV. Methods Biochemical iron parameters and gene expression analysis were carried out in 20 individuals with transfusion-dependent thalassemia (TDT), 20 individuals with non-transfusion-dependent thalassemia (NTDT), 25 individuals affected with PV, and 50 healthy controls. Results Increased soluble transferring receptor (sTfR) levels in both diseases are evidence of increased erythropoietic activity. Compa

SUBMITTER: Santhakumar S 

PROVIDER: S-EPMC12550385 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature