Efficacy & safety of stem cell therapy for treatment of acute myocardial infarction: A systematic review & meta-analysis.

ABSTRACT: Background & Objectives Stem cell based therapeutic treatments have been used as a management strategy for acute myocardial infarction (AMI), a common primary factor causing death globally. We aimed to undertake a meta-analysis of studies including randomised controlled trials (RCTs) examining different stem cell preparations in AMI, as a definitive answer from this therapeutic approach is yet to emerge. Methods Following PROSPERO registration (CRD42024628552), a systematic search was conducted through PubMed database, Embase, Cochrane, and Web of Science. Data was analysed using RevMan 5.4.1. Primary outcomes included all-cause mortality, recurrent myocardial infarction (Re-MI), severe adverse events (SAEs), hospitalisation for heart failure, cancer incidence, and left ventricular ejectio

SUBMITTER: Aggarwal P 

PROVIDER: S-EPMC12550445 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature