Neural Signatures of Cognitive Control Predict Future Adolescent Substance Use Onset and Frequency.

ABSTRACT:

Background

Adolescent substance use is a significant predictor of future addiction and related disorders. Understanding neural mechanisms underlying substance use initiation and frequency during adolescence is critical for early prevention and intervention.

Methods

The current longitudinal study followed 91 substance-naïve adolescents annually for 7 years from ages 14 to 21 years to identify potential neural precursors that predict substance use initiation and frequency. Cognitive control processes were examined using the Multi-Source Interference Task to assess functional neural connectivity. A questionnaire was used to assess substance use frequency.

Results

Stronger connectivity between the dorsal anterior cingulate cortex (dACC) and dorsolateral prefrontal cortex

SUBMITTER: Chen YY 

PROVIDER: S-EPMC12550502 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature