Elevated inflammation supra-additively promotes the progression from prediabetes to diabetes: a prospective cohort study.

ABSTRACT:

Background

Factors impacting on the conversion of prediabetes to diabetes or normoglycemia remain unclear. This study aimed to investigate the role of subclinical inflammation, assessed by high-sensitivity C-reactive protein (hsCRP), in the progression to diabetes from prediabetes, assessed by impaired fasting glucose (IFG).

Methods

Time-to-event survival analyses were conducted among 82 475 participants without diabetes from Kailuan Study (a real-life prospective cohort in China) to access the isolated and joint effect of hsCRP and IFG on diabetes risk, and quantify their relative contribution to incident diabetes.

Results

Over a median 11-year follow-up, 14 215 diabetes cases were recorded. IFG and hsCRP independently and jointly increased diabetes risk. Diabetes in

SUBMITTER: Lan Y 

PROVIDER: S-EPMC12550539 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature