Foreign Body Granulomas Reaction Related to Collagen Stimulatory Cosmetic Fillers: A Systematic Review.

ABSTRACT:

Background

Collagen-stimulating filler has boomed as a new welcoming option in aesthetic treatments by activating the synthesis of endogenous collagen. However, hyperactive or inappropriate foreign-body stimulatory reactions may trigger intractable foreign body granulomas (FBGs). A comprehensive understanding of the FBGs associated with the augmenting effect of collagen biostimulants can help clinicians perform treatments in a safer and more effective way.

Methods

A literature search was conducted in Web of Science, PubMed, Embase, and Scopus to identify relevant clinical reports about the FBGs induced by six types of commercially available collagen stimulators up to August 2024.

Results

A total of 40 studies involving 117 patients were included. All but eight cases w

SUBMITTER: Wang H 

PROVIDER: S-EPMC12550546 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature