Meta-analysis of surrogate endpoints for overall survival in extensive-stage small-cell lung cancer.

ABSTRACT:

Background

Overall response rate (ORR), disease control rate (DCR), and progression-free survival (PFS) are traditionally used as surrogates for overall survival (OS). However, their validity as reliable predictors of OS in small-cell lung cancer (SCLC) remains unclear.

Materials and methods

MEDLINE, Embase, Cochrane, and ClinicalTrials.gov were systematically searched between 2014 and 2024. Study selection followed PRISMA guidelines. Data on ORR, DCR, PFS, and OS were manually extracted from phase III randomized trials. Weighted linear regression and Pearson correlation analyses, with logarithmic transformation of odds ratios and hazard ratios, were used to assess associations between endpoints. Correlation coefficients were computed to evaluate the correlation between surr

SUBMITTER: Durer S 

PROVIDER: S-EPMC12550574 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature