Associations of angiopoietin-like protein 7 with coronary collateral circulation and prognosis of patients with severe coronary artery stenosis.

ABSTRACT:

Background

Angiogenesis and coronary collateral circulation (CCC) formation promote cardiac repair following severe coronary stenosis (SCS) or myocardial infarction (MI). Angiopoietin-like protein 7 (ANGPTL7) is a secreted protein associated with angiogenesis, but its role in CCC formation remains unclear.

Objective

The aim of this study was to investigate the role of ANGPTL7 in angiogenesis and evaluate the predictive value of serum ANGPTL7 in CCC formation and the prognosis of patients with SCS.

Materials and methods

The RNA sequencing was performed on myocardial tissues of mice to analyze the alterations of angiogenesis-related genes after MI. 100 patients with angiographically proven SCS and 36 controls were enrolled and retrospectively followed up. Serum ANGPTL7

SUBMITTER: Cheng C 

PROVIDER: S-EPMC12550588 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature