Association of Elevated Serum S100A8/A9 Levels and Cognitive Impairment in Patients With Systemic Lupus Erythematosus.

ABSTRACT:

Objective

Cognitive impairment (CI) is common in patients with systemic lupus erythematosus (SLE). Despite its prevalence, the immune mechanisms are not well understood. We previously reported elevated serum levels of S100A8/A9 and matrix metalloproteinase 9 (MMP-9) in patients with SLE and CI. This study aims to validate those findings by examining the relationship between serum levels and CI in patients with SLE at baseline and after one year.

Methods

We assessed cognitive function in 112 patients with SLE using the adapted American College of Rheumatology-Neuropsychological Battery, defining CI as impairment in two or more domains. Serum S100A8/A9 and MMP-9 levels were measured by enzyme-linked immunosorbent assay. We compared serum levels between CI and non-CI groups, ev

SUBMITTER: Munoz-Grajales C 

PROVIDER: S-EPMC12550649 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature