Systemic inflammatory biomarkers in relation to lung function and exercise-induced bronchoconstriction in adolescents.

ABSTRACT:

Introduction

The forced oscillation technique (FOT) complements spirometry in assessing lung function, with higher sensitivity to small airway dysfunction. Systemic inflammation is thought to influence lung development and exercise-induced bronchoconstriction (EIB), but its relationship to circulating inflammatory proteins in adolescents is unclear.

Objective

To investigate associations between systemic inflammatory biomarkers and baseline lung function and post-exercise airway responses in adolescents.

Methods

In 143 adolescents (13-15 years) from a population-based cohort, baseline spirometry, FOT, and baseline blood samples were obtained. Participants completed an exercise challenge to assess EIB via changes in forced expiratory volume in 1 s (FEV₁), res

SUBMITTER: Ersson K 

PROVIDER: S-EPMC12550650 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature