Clinical outcomes of isolated versus systemic cardiac sarcoidosis: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Isolated cardiac sarcoidosis (ICS) is characterized by a lack of the apparent extra-cardiac involvement seen in systemic cardiac sarcoidosis (SCS) and is being increasingly recognized as a distinct clinical phenotype of cardiac sarcoidosis. This systematic review and meta-analysis pooled data from published literature to assess any differences in outcomes of ICS vs. SCS patients.

Methods

Studies were identified from PubMed/Medline, Embase, and the Cochrane Library. Risk ratios were calculated using the Mantel-Haenszel method in a random effects model. Heterogeneity was assessed using the Higgins I ² statistic. Leave-one-out sensitivity analysis was also performed. The primary outcome was a composite of MACE, including cardiac death, ventricular

SUBMITTER: Ahmed R 

PROVIDER: S-EPMC12550700 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature