Bone marrow and blood demonstrate distinct immune reconstitution patterns and correlations with relapse posttransplant.

ABSTRACT:

Abstract

The bone marrow represents the tumor microenvironment for many hematologic malignancies and a potentially critical site for alloimmunity after hematopoietic transplantation. Despite the importance of immune reconstitution (IR) after transplant, marrow IR data are limited, and insights are largely derived from studies of peripheral blood (PB). We investigated lymphocyte IR longitudinally in marrow (n = 110) and PB samples (n = 115) from adults undergoing allogeneic transplantation for hematologic malignancies (n = 33). This transplant cohort included a diverse representation of graft sources (mobilized PB, CD34-selected grafts, and umbilical cord blood) and degrees of HLA mismatch. Natural killer (NK) cells quickly expanded within the first 30 days after transplant in both

SUBMITTER: DeWolf S 

PROVIDER: S-EPMC12550711 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature