Gestational low-protein diet impairs mitochondrial function and skeletal muscle development by inducing immune responses in male offspring.

ABSTRACT: Maternal nutrition is essential for proper fetal and postnatal organ maturation and is linked to the future risk of developing metabolic syndrome, cardiovascular disease, and muscle loss. There is still limited understanding how a low-protein intake during gestation influences skeletal muscle development, inflammation, and the related pathways. This study aimed to investigate the impact of gestational low-protein diet in mice on skeletal muscle development and inflammatory responses in male offspring. Pups born from mothers fed a low-protein diet (LPD) were lactated by normal protein diet (NPD)-fed mothers and maintained on NPD post-weaning (LNN group). Offspring born from mothers fed an NPD and maintained on an NPD during lactation and beyond were used as controls (NNN group). In 21-day-o

SUBMITTER: Altinpinar AE 

PROVIDER: S-EPMC12550721 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature