Biological Sex and Chronic Rhinosinusitis Diagnosis and Biomarkers.

ABSTRACT:

Importance

The inflammation-modulating properties of sex hormones provide a pathophysiological basis for anticipating sex-based differences in chronic rhinosinusitis (CRS), but the role of biological sex has not been thoroughly studied.

Objectives

To investigate sex differences in CRS diagnosis and biomarkers.

Design, setting, and participants

This cross-sectional study used data from the All of Us Research Program, a large national dataset of US adults, collected from partner health care organizations including academic medical centers, Veterans Affairs facilities, and community health centers. From May 2018 to October 2023, a total of 393 596 participants with electronic health records were considered for inclusion; those with incomplete data were excluded. Data ana

SUBMITTER: Chiu RG 

PROVIDER: S-EPMC12550736 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature