Inhibitory effects of β-galactoside α2,6-sialyltransferase 1 on the Hippo pathway in breast cancer cells.

ABSTRACT: The Hippo signaling pathway is crucial in various pathological functions, such as tumor development. Yes-associated protein (YAP), a well-known downstream effector of the Hippo pathway, has been intensively studied; emerging evidence suggests that multiple cell membrane receptors can regulate the Hippo pathway. However, the mechanistic roles of these upstream pathways remain largely unknown. Here, we identified the β-galactoside α2,6-sialyltransferase 1 (ST6GAL1) catalyzed α2,6-sialylation as a pivotal upstream modulator of Hippo pathway by a glycosyltransferases overexpression sublibrary screening. Depletion of ST6GAL1 results in increased phosphorylation of large tumor suppressor kinase 1 and YAP, which induces YAP's nuclear localization, transcriptional activity, and multiple biological

SUBMITTER: Hang Q 

PROVIDER: S-EPMC12550800 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature