Prenatal Organophosphate Pesticide Exposure and Targeted Maternal Pregnancy Metabolomic Profiles in the NYU CHES Cohort.

ABSTRACT: Prior research links prenatal exposure to organophosphate (OP) pesticides to adverse health outcomes via molecular mechanisms, such as oxidative stress, neurotransmitter disruption, and mitochondrial dysfunction. This study investigates such mechanisms by assessing the relationships between prenatal OP pesticide exposure and targeted urinary maternal metabolomic profiles using data from the New York University Children's Health and Environment Study (NYU CHES) cohort (n = 890). Urine samples were collected at three time points during pregnancy (T₁, T₂, T₃) and analyzed for six dialkyl phosphate (DAP) metabolites and a targeted set of 188 metabolites related to key biological functions. Associations between DAP concentrations and

SUBMITTER: Cavalier H 

PROVIDER: S-EPMC12550812 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature