Mechanistic Dissymmetry between Crystal Growth and Dissolution Drives Ratcheted Chiral Amplification.

ABSTRACT: Complete chiral amplification of the solid phase arises when mixtures of self-sorting enantiopure crystals undergo cycles of crystal growth and dissolution under solution-phase racemizing conditions. However, despite extensive studies and widespread use, the mechanism underlying such crystallization-induced deracemization remains insufficiently understood, hindering its optimization and broader application. Here, we experimentally dissect the individual contributions of crystal growth and dissolution and use a mass-balance to expose crystal dynamics. Regardless of the racemization rate, we always find a dissymmetry between the growth and the dissolution of the enantiomer populations. These experiments suggest that a fundamental difference between the mechanisms of crystal growth and dissol

SUBMITTER: van Dongen SW 

PROVIDER: S-EPMC12550841 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature