Synthesis of Sterically Congested Carbonyl Compounds via an <i>ipso</i>-Selective Sulfonium Rearrangement.

ABSTRACT: Despite the success of metal-catalyzed cross-coupling strategies to assemble a variety of C-C bonds, the synthesis of sterically congested α-arylated carbonyl compounds remains a difficult task. Herein, we present an ipso-rearrangement approach relying on electron redistribution in sulfonium intermediates. This modular method enables the synthesis of a variety of α-arylated carbonyl compounds and is orthogonal to traditional metal-catalyzed cross-coupling strategies. More importantly, it demonstrated remarkable robustness toward steric hindrance and allowed us to efficiently forge congested C-C bonds.

SUBMITTER: Klose I 

PROVIDER: S-EPMC12550846 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature