The Effects of the Crohn's Disease Exclusion Diet (CDED) Alone Versus CDED Plus Partial Enteral Nutrition (PEN) on Gut Microbiome Composition in Pediatric CD Patients.

ABSTRACT: Crohn's disease (CD) is a chronic inflammatory bowel condition characterized by relapsing inflammation and microbial dysbiosis. Diet-based therapies have emerged as promising adjuncts in pediatric CD management. To our knowledge, this is the first randomized trial to directly compare Crohn's Disease Exclusion Diet (CDED) with and without Partial Enteral Nutrition (PEN) in pediatric Crohn's patients from a microbiome perspective, highlighting the potential clinical relevance of dietary strategies that are more feasible than exclusive enteral nutrition. In this randomized controlled trial, 60 children with mild-to-moderate CD were assigned to either a CDED-only group or a CDED + PEN group. Gut microbiota composition was assessed using quantitative PCR before and after the 8-week intervention

SUBMITTER: Rohani P 

PROVIDER: S-EPMC12550864 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature