Clinical, Endoscopic and Histologic Differences in Gastric Mucosa Between Younger and Older Adults: An Observational Study on the Aging Stomach.

ABSTRACT:

Background/objectives

Age-related changes in the gastric mucosa remain incompletely understood. We aimed to assess and compare clinical, endoscopic and histologic changes in the gastric mucosa associated with aging, and to explore whether gastric aging is associated with a distinct histological pattern.

Methods

Single-center observational study. Younger (18-45 years) and older (≥70 years) adults undergoing elective upper endoscopy were included and underwent gastric biopsies. The clinical, endoscopic and histologic features were analyzed and compared.

Results

A total of 100 patients were included (45 men/55 women), 50 with 18-45 years and 50 with ≥70 years. Dyspepsia, gastro-esophageal reflux disease and peptic ulcer disease were the most common indications for upper

SUBMITTER: Vara-Luiz F 

PROVIDER: S-EPMC12550935 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature