Monoclonal Antibodies Can Aid in the Culture-Based Detection and Differentiation of <i>Mucorales</i> Fungi-The Flesh-Eating Pathogens <i>Apophysomyces</i> and <i>Saksenaea</i> as an Exemplar.

ABSTRACT:

Background

The frequency of necrotising cutaneous and soft tissue infections caused by the Mucorales fungi Apophysomyces and Sakasenaea is increasing. The absence of sophisticated diagnostic technologies in low- and middle-income countries (LMICs) means that detection of cutaneous mucormycosis continues to rely on culture of the infecting pathogens from biopsy and their differentiation based on morphological characteristics. However, Apophysomyces and Sakasenaea are notorious for their failure to sporulate on standard mycological media used for the identification of human pathogenic fungi. Differentiation of these pathogens and their discrimination from Aspergillus fumigatus, the most common mould pathogen of humans, is essential due to the

SUBMITTER: Thornton CR 

PROVIDER: S-EPMC12550967 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature